This story was updated on Tuesday, Nov. 4, 2025, at 10:24 p.m.
A UPS cargo plane crashed and exploded in a massive fireball Tuesday while taking off from the company’s global aviation hub in Louisville, Kentucky, killing at least seven people and injuring 11, authorities said.
The plane crashed about 5:15 p.m. as it was departing for Honolulu from UPS Worldport at Louisville Muhammad Ali International Airport.
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