A new discovery in the muscles of long COVID patients may explain exercise troubles

For patients with long COVID, exercise can lead to a worsening of symptoms, a condition called post-exertional malaise. New research shows what's going on in their muscles.

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Hit the gym. Get back in shape.

That’s what many patients with long COVID are told when they talk of the crushing fatigue that envelops them after even a light bout of physical activity.

These symptoms of exhaustion, or post-exertional malaise as it’s called, are a hallmark of long COVID and similar complex illnesses like chronic fatigue syndrome or ME/CFS.